The most recommended dose is a hundred mg and It is far from advisable to just take multiple dose on a daily basis. Sildenafil may be taken with or without the need of food items, but having it having a large-Unwanted fat meal may increase the time prior to the medication starts Doing work.
The suggest continuous state quantity of distribution (Vss) for sildenafil is 105 L, indicating distribution into your tissues. Sildenafil and its main circulating N-desmethyl metabolite are both of those around ninety six% sure to plasma proteins. Protein binding is independent of whole drug concentrations.
VIAGRA was proven to potentiate the hypotensive consequences of nitrates and its administration in sufferers who use nitric oxide donors such as natural nitrates or natural and organic nitrites in any kind is as a result contraindicated [see CONTRAINDICATIONS, DRUG INTERACTIONS, and Scientific PHARMACOLOGY].
PDE3 is involved in command of cardiac contractility. Sildenafil is just about ten-fold as powerful for PDE5 as compared to PDE6, an enzyme found in the retina which is associated with the phototransduction pathway of your retina. This reduced selectivity is considered The idea for abnormalities associated with shade eyesight [see Pharmacodynamics].
It's eradicated predominantly by hepatic metabolism (mainly CYP3A4) and it is transformed to an Lively metabolite with Qualities just like the mother or father, sildenafil. Both equally sildenafil and also the metabolite have terminal 50 % life of about 4 hours.
This metabolite contains a PDE selectivity profile comparable to sildenafil and an in vitro potency for PDE5 roughly 50% on the guardian drug. Plasma concentrations of the metabolite are somewhere around 40% of All those observed for sildenafil, so the metabolite accounts for around 20% of sildenafil's pharmacologic effects.
This rare problem is a lot more very likely to come about Should you have heart problems, superior hypertension, large cholesterol, diabetes, or eye challenges, are greater than 50 years old, or in case you smoke. If you have any eye problems, for instance retinitis pigmentosa or
Your physician might have instructed this medication for ailments besides People shown in these drug information and facts content.
The main indication of sildenafil is procedure of erectile dysfunction (lack of ability to sustain a satisfactory erection to finish sexual intercourse). Its use has become on the list of normal treatment plans for erectile dysfunction, which includes for males with diabetes mellitus.[18]
†Irregular Eyesight: Delicate and transient, predominantly colour tinge to eyesight, but additionally amplified sensitivity to mild or blurred eyesight. In these research, just one affected person discontinued because of abnormal eyesight.
Use an correct measuring gadget to evaluate your dose of sildenafil oral liquid. A residence spoon is not really an correct measuring machine and will bring about you to definitely acquire the wrong dose. Ask your pharmacist to suggest an correct measuring machine.
Physicians really should advise sufferers to halt taking PDE5 inhibitors, together with VIAGRA, and request prompt health care attention while in the party of unexpected reduce or loss of hearing. These situations, which can be accompanied by tinnitus and dizziness, are already described in temporal Affiliation to the intake of PDE5 inhibitors, which includes VIAGRA.
Halt sexual exercise and have healthcare aid without delay if you get signs for example upper body suffering, dizziness, or nausea all through sexual intercourse.
In These patients already having an optimized dose of the PDE5 inhibitor, alpha-blocker therapy ought to be initiated at the bottom dose. Stepwise increase in alpha-blocker dose might be related to additional reducing of blood get more info pressure when getting a PDE5 inhibitor.